Neurophysiology

Large scale neural recordings from in-vivo and in-vitro non-human mammalian brains use optical and electrical techniques. Data obtained from these recordings are used for building large scale machine learning algorithm based models that predict neural responses from visual stimuli.

Publications

NEURD offers automated proofreading and feature extraction for connectomics

Brendan Celii, Stelios Papadopoulos, Zhuokun Ding, Paul G. Fahey, Eric Wang, Christos Papadopoulos, Alexander B. Kunin, Saumil Patel, et al.

Nature, 640, 487-496, 2025

Foundation model of neural activity predicts response to new stimulus types

Eric Y. Wang, Paul G. Fahey, Zhuokun Ding, Stelios Papadopoulos, Kayla Ponder, Marissa A. Weis, Andersen Chang, Taliah Muhammad, Saumil Patel, et al.

Nature, 640, 470-477, 2025

Functional connectomics reveals general wiring rule in mouse visual cortex

Zhuokun Ding, Paul G. Fahey, Stelios Papadopoulos, Eric Y. Wang, Brendan Celii, Christos Papadopoulos, Andersen Chang, Alexander B. Kunin, Dat Tran, Jiakun Fu, Zhiwei Ding, Saumil Patel, et al.

Nature, 640, 459-469, 2025

Functional connectomics spanning multiple areas of mouse visual cortex

J. Alexander Bae, Mahaly Baptiste, Maya R. Baptiste, Caitlyn A. Bishop, Agnes L. Bodor, Derrick Brittain, Victoria Brooks, JoAnn Buchanan, Daniel J. Bumbarger, Manuel A. Castro, Brendan Celii, et al.

Nature, 640, 435-447, 2025

A wireless subdural-contained brain–computer interface with 65,536 electrodes and 1,024 channels

Taesung Jung, Nanyu Zeng, Jason D. Fabbri, Guy Eichler, Zhe Li, Erfan Zabeh, Anup Das, Konstantin Willeke, Katie E. Wingel, Agrita Dubey, Rizwan Huq, Mohit Sharma, Yaoxing Hu, et al.

Nature Electronics, 8, 1272–1288, 2025

Temporal coding carries more stable cortical visual representations than firing rate over time

Hanlin Zhu, Fei He, Pavlo Zolotavin, Saumil Patel, Andreas S. Tolias, Lan Luan & Chong Xie

Nature Communications, 16, 7162, 2025

Cellular composition and circuit organization of the locus coeruleus of adult mice

McKinney, A., Hu, M., Hoskins, A., Mohammadyar, A., Naeem, N., Jing, J., Patel, S.S., Sheth, B.R., Jiang, X.

Elife, doi: 10.7554/eLife.80100, 2023

Sustained deep-tissue voltage recording using a fast indicator evolved for two-photon microscopy

Liu Z., Lu, X., Gou, Y., Villette, V., Colbert, K. L., Lai, S., Guan, S., Land, M., Lee, J., Assefa, T., Korympidou, M. M., Franke, F., Vlasits, A. L., Pang, M. M., Su, S., Froudarakis, E., Zhou, N., Patel, S. S., et al.

Cell, doi: 10.1016/j.cell.2022.07.013, 2022

State-dependent pupil dilation rapidly shifts visual feature selectivity

Franke, K., Willeke, K. F., Ponder, K, Galdamez, M., Muhammad, T., Patel, S. S., Froudarakis, E., Reimer, J., Sinz, F. and Tolias, A. S.

Nature, doi: 10.1038/s41586-022-05270-3, 2022

Layer 4 of mouse neocortex differs in cell types and circuit organization between sensory areas

Scala F, Kobak D, Shan S, Bernaerts Y, Laturnus S, Cadwell RC, Hartmanis L, Froudarakis E, Castro J, Tan ZH, Papadopoulos S, Patel, S. S, Sandberg R, Berens P, Jiang X, Tolias AS

Nat. Comm. 2019 Sep 13;10(1):4174

Faster processing of moving compared to flashed bars in awake macaque V1 provides a neural correlate of the flash lag illusion

Subramaniyan, M., Ecker, A. S., Patel, S. S., Cotton, R. J., Bethge, M., Berens, P. and Tolias, A. S.

J. Neurophysiology, doi:10.1152/jn.00792.2017, 2018

Response to Comment on "Principles of connectivity among morphologically defined cell types in adult neocortex"

Jiang, X., Shen, S., Sinz, F., Reimer, J., Cadwell, C. R., Berens, P., Ecker, A. S., Patel, S. S., Denfield, G. H., Froudarakis, E., Li, S., Walker, E., Tolias, A. S.

Science, doi: 10.1126/science.aaf6102, 2016

Principles of connectivity among morphologically defined cell types in adult neocortex

Jiang, X., Shen, S., Cadwell, C. R., Berens, P., Sinz, F., Ecker, A. S., Patel, S. S., Tolias, A. S.

Science, doi: 10.1126/science.aac9462, 2015